Aceclofenac Tablets

Aceclofenac BP 100mg is an orally administered phenylacetic acid derivative belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDS), related to diclofenac. Through it’s analgesic and anti-inflammatory properties, Aceclofenac provides symptomatic relief in a variety of painful conditions.

The mode of action of Aceclofenac is largely based on the inhibition of prostaglandins synthesis. Aceclofenac is a potential inhibitor of the enzyme Cyclooxygenase, which is invloved in the production of prostaglandins.

Clinical pharmacokinetics
Absorption
Aceclofenac is rapidly and completely absorbed after oral administration and it’s bioavailability is almost 100%. Peak plasma concentrations are reached 1 to 3hours after an oral dose. T-max is delayed with concomitant food intake wheras the degree of absorption is not influenced.

Distribution and metabolism
The plasma concentration of Aceclofenac was approximately twice that in synovial fluid after multiple doses of the drug in patients with knee pain and synovial fluid effusion.

Aceclofenac is probably metabolised via CYP2C9 to themain metabolite 4-Hydroxyaceclofenac and to a number of other metabolites including 5-Hydroxyaceclofenac, 4′-Hydroxydiclofenac, Diclofenac and 5-Hydroxydiclofenac.

The volume of distribution is approximately 30L. Aceclofenac is highly protein bound (99%).

Elimination
Renal excretion is the main route of elimination of Aceclofenac with 70 to 80% of an administered dose found in the urine, mainly as the Glucuronides of Aceclofenac and it’s metabolites of each dose of Aceclofenac. 20% is excreted in the faeces.

The plasma elimination half-life of the drug is approximately 4hours. Only 1% of an oral single dose is excreted unchanged.

A slow rate of elumination of Aceclofenac has been detected in patients with decreased liver function after a single dose of Aceclofenac.

Indications
It is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

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